Because this region is broadly associated with numerous diseases, including cancers [27–29], autoimmune [30–32] and infectious diseases [33], etc. Diverse genetic interactions among MHC, Killer-cell Immunoglobulin-like Receptors (KIRs) and T-cell Receptors (TCRs) are also reported in human populations [34–36]. This evidence concerns the gene HLA-C and infectious disease.