The larger extension of fibrosis as observed in SHR after laceration in comparison with WR (Fig 1D and 1E) and fibrosis reduction after treatment with Lv-mirAT1a (Fig 4D and 4F) were the first evidence of correlation between fibrosis and hypertension in the skeletal muscle, indicating that AT1-mediated hypertension should be the main cause of fibrosis in the skeletal muscle. The gene discussed is AGTR1; the disease is hypertensive disorder.