TLR4 and rheumatoid arthritis: MiR-223 is involved in granulocyte activation, and is overexpressed in naïve CD4+ T-lymphocytes in patients with rheumatoid arthritis.[24] MiR-146 is upregulated in monocytes in response to LPS and downregulates genes involved in the signal transduction pathway of TLR4 signaling,[15] and miR-203 is enhanced in skin of patients with psoriasis.[25]