DPEP1 and colorectal cancer: MEP1A (metalloproteinase meprin A) is a susceptibility gene for IBD, expressed in intestinal epithelium.[36] ALDOB (Aldolase B) is a member of the aldolase family, expression of which was found to be reduced in chronic transfer colitis.[37] DPEP1 (dipeptidase-1) has not been described to play a role in gastro-intestinal inflammation, but is expressed in colorectal cancer where it negatively correlates to aggressive disease and poor prognosis.[38]