TYK2 and systemic lupus erythematosus: By plotting the cis-eQTL P-values alongside the JLIM P-values for all exons and introns of TYK2 against rs2304256 (Fig 2D), we clearly show that only a single exon and a single intron of TYK2 colocalize with the SLE association signal–marked by an asterisk (note that rs2304256 is a strong cis-eQTL for many introns of TYK2 but only shares a causal variant with one intron).