ARHGDIA and gastric cancer: Interestingly, a synthetic peptide corresponding to amino acids 331-346 derived from ephrinB1 suppresses RhoA activation and gastric cancer cell migration and dissemination.46 This peptide represents the C terminus, including four amino acids that overlap with the critical region identified here (aa 327–334) that is required for the interaction with RhoGDI1 (46; Figure 2c).