RHO and osteosarcoma: Several studies have indicated that the expression of ephrinB1 is upregulated in multiple cancers, such as osteosarcomas, hepatocellular carcinoma, gastric adenocarcinoma, and medulloblastoma.50, 51, 52, 53 The present study has revealed an important mechanism by which ephrinB1 regulates cancer cell aggressiveness through Rho activity.