EPHA1 and cancer: Cancer cells generally use two modes of migration; one is mesenchymal migration where a partial loss of cell polarity occurs along with the development of a fibroblast-like morphology, and another is ameboid migration in which polarity is completely disrupted and protrusions form and align in the direction of migration.47 Eph/ephrin interactions can affect contact inhibition of locomotion (CIL) where migrating cells pause in response to contact with other cells, which leads to retraction of cell protrusions, repolarisation, and cells migrate away from each other.