It was recently reported that a G173V mutant RhoGDI1 was identified in nephrotic syndrome patients, and this mutant does not interact with RhoGTPase family proteins, such as RhoA, Rac1 and Cdc42.42 If this mutant is still capable of associating with ephrinB1, its overexpression may abrogate the EphB2-Fc-induced interaction of ephrinB1 with endogenous RhoGDI1. Here, EPHB2 is linked to nephrotic syndrome.