The abnormal expression of NTSR2, independent of B-CLL stage and progression, led us to investigate the roles of the primary mechanisms responsible for GPCR overexpression, that is, gene mutations and chromosomal abnormalities.9 To this end, we sequenced NTSR2 and analyzed the karyotypes of 10 B-CLL patients. The gene discussed is NTSR2; the disease is B-cell chronic lymphocytic leukemia.