A cross-pathway interaction between GPCRs and TKRs was previously reported for another NTS receptor, NTSR1 and EGFR/HERs in lung, breast and hepatocarcinomas.12, 17, 43 In leukemias or lymphomas, NTSR1 has been characterized in Sezary syndrome and HL-60 cells,44, 45 whereas NTSR2 has rarely been investigated in cancers, with the exception of prostatic cancer.46 Here, EGFR is linked to Familial prostate cancer.