The profile of NTSR2 expression, which was similar between indolent and progressive B-CLL, was independent of B-CLL markers such as TP53 deletion, IGHV mutation, 13q14 deletion and CD38 expression, indicating that NTSR2 does not represent a discriminant marker for B-CLL stage (Figure 1b). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.