Giα protein recruitment in immune cells plays a central role in B-lymphocyte survival, especially in regard to control of Bcl-2 expression, as demonstrated in Giα-deficient mouse models showing that downregulated expression of Bcl-2 family proteins.47 That, decreases the B-1a B-lymphocyte subpopulation,48 equivalent to B-CLL lymphocytes. Here, BCL2 is linked to B-cell chronic lymphocytic leukemia.