These data are consistent with our previous results showing that NTSR1 and NTSR2 and their common ligand NTS are involved in fine-tuned regulation of normal B-lymphocyte survival.14 However, in B-CLL lymphocytes, NTSR2 was drastically overexpressed, whereas NTS and NTSR1 were strongly downregulated. This evidence concerns the gene NTSR2 and B-cell chronic lymphocytic leukemia.