BCR and B-cell chronic lymphocytic leukemia: Independently of BCR activation, several pro-survival B-CLL growth factors and non-BCR receptors have been implicated in the pathogenesis of B-CLL,31 including Notch,32 TKR receptors such as insulin-like growth factor-1 receptor,33, 34 and chemokines and their associated GPCRs.35, 36, 37, 38, 39 However, other GPCRs have not previously been reported to be involved in B-CLL pathogenesis.