The PROMIS group recently reported a confirmatory study testing diagnostic accuracy of multiparametric MRI (MP-MRI) and transrectal ultrasound (TRUS)-guided biopsy results versus template prostate mapping biopsy as a reference test for men with PSA up to 15 ng/mL.66 On template biopsy, 71% of men were diagnosed with prostate cancer and 40% had clinically significant cancer. The gene discussed is KLK3; the disease is Familial prostate cancer.