‘Upregulated genes’ were investigated for their representation in KEGG pathways by WebGestalt.24 KEGG pathways enriched in this set of genes included several pathways known to be involved in the cross-talk between CAFs and cancer cells, metabolic pathways, cytokine–cytokine receptor interaction, pathways implicated in cancer, the Jak-STAT signaling pathway, and the MAPK signaling pathway (Supplementary Figure S3B). Here, SOAT1 is linked to cancer.