Of the 109 patients analyzed, the majority were men (72.5%); the mean age (±SD) was 52.0 ± 15.9 years; 29.4% were of normal weight (body mass index [BMI] <25 kg/m2), 35.8% were overweight (BMI 25–30 kg/m2), and 33.9% were obese (BMI ≥30 kg/m2); median [interquartile range] duration of DM was 17 [10; 25] years: 53.8% of the patients had type 1 DM and 87.2% had been injecting insulin for more than 3 years (Table 1). This evidence concerns the gene INS and diabetes mellitus.