Indeed, since cases of juvenile osteoporosis have been ascribed to inactivating mutations of the type 1 collagen (COL1A1), ERalpha (ERα), aromatase (CYP19), and low-density lipoprotein receptor-related protein 5 (LRP5) genes, the sequencing of these genes can be performed. This evidence concerns the gene COL1A1 and idiopathic juvenile osteoporosis.