This suggests a direct inhibition of β-catenin-dependent WNT signaling by PCP via PRICKLE1. Another recent publication focused on transcriptome analyses and computational interaction studies in NB, melanoma and colorectal carcinoma, and provided data that correlate high WNT3A, WNT5A, APC, or FZD10 expression with longer event-free survival, while high WNT3 or FZD1 indicates less favorable outcome [85]. This evidence concerns the gene WNT5A and neuroblastoma.