β-catenin signalling decreases the migration of melanocytes and melanoma cell lines in vitro but promotes lung metastases in the NRAS-driven melanoma murine model15 and also in a murine model, it has already been observed that ROCK activates beta-catenin and causes epidermal hyperplasia in murine skin by actomyosin contractility and increased epidermal cell proliferation16. The gene discussed is NRAS; the disease is melanoma.