Using atherosclerosis-susceptible mouse models with ubiquitous deletion of Panx1 (Panx1−/−Apoe−/−) or with Cre recombinase-mediated deletion of Panx1 in endothelial cells and monocytes (Tie2-CreTgPanx1fl/flApoe−/−; Panx1delApoe−/−), we identified a novel role for Panx1 in the lymphatic vasculature. This evidence concerns the gene TEK and atherosclerosis.