Moreover, CCR2 rs1799864A allele frequency was significantly higher among mild and severe JE cases than controls (mild JE cases: 54.16% vs. control: 36.50%, P = 0.01; severe JE cases: 26.22% vs. controls: 12.23%, P = 0.002) (Supplementary Table S2). This evidence concerns the gene CCR2 and Japanese encephalitis.