To extend our molecular studies to a more biologically relevant and disease-related paradigm, we determined basal Mcl-1 protein expression along with other anti- and pro-apoptotic Bcl-2 family members in tumor samples from patients with anaplastic astrocytoma stratified according to the presence or absence of the IDH1-R132H mutation. The gene discussed is BCL2; the disease is anaplastic astrocytoma.