As anticipated, treatment with ABT263 and 2-HG resulted in a synergistic increase in the fraction of annexin V-positive (apoptotic) U87MG, LN229, T98G, and SF188 glioblastoma cells and the fraction of subG1 cells in SF188 pediatric glioblastoma cells (Fig. 2h and Supplementary Fig. 3A–C). Here, ANXA5 is linked to glioblastoma.