The activation of NF-κB by Notch-4/Int3 indicates that in addition to a role for Notch in proliferation, differentiation, and survival of tumor cells44,55, Notch-4/Int3 may also have critical functions in the immune response, inflammation, viral infection, and apoptosis through control of NF-κB-mediated gene expression. The gene discussed is NOTCH4; the disease is neoplasm.