Consistent with MEK involvement, genes repressed by MEK activation are under-represented in prostate tumors from Foxp1-Shq1f/f;Ptenf/f mice relative to Ptenf/f mice at 12 months, as assessed by GSEA of RNA-seq expression data (P = 0.004, FDR = 0.05, GSEA, Supplementary Fig. 5e). This evidence concerns the gene MAP2K7 and prostate neoplasm.