Since the human 3p13-14 locus more commonly exhibits mono-allelic loss than bi-allelic deletion in prostate cancer and its component genes show an average 1.5-fold reduction in RNA expression upon mono-allelic loss3, the Foxp1-Shq1f/f;Ptenf/f mouse model exhibits similar level of 3p13-14 gene expression change to that of human disease. The gene discussed is FOXP1; the disease is prostate carcinoma.