Genes within the Foxp1-Shq1 interval, including Shq1, Foxp1, Eif4e3, Prok2, and Rybp, also show decreased RNA expression in Foxp1-Shq1f/f;Ptenf/f prostates compared to Ptenf/f alone (by quantitative PCR, Fig. 2c; by RNA-seq, Fig. 2d), similar to human prostate cancers with the deletion. This evidence concerns the gene PROK2 and prostate carcinoma.