The spastic paraplegia 7 gene (SPG7) is located in the long (q) arm of chromosome 16 at position 24.3.Protein product of SPG 7 gene Paraplegin is involved in the maintenance of mitochondrial function by forming a part of the mitochondrial multimeric mAAA metaloprotease complex.1,2 More than 77 different mutations of the SPG7 gene have been described in the literature so far.3 Mutation is the SPG7 is responsible for autosomal recessive Hereditary Spastic Paraparesis (ARHSP). The gene discussed is SPG7; the disease is paraplegia.