For comparison, in another, similarly sized dystonia-linked protein (THAP1 [THAP domain containing 1], 213 amino acids), ExAC reports a missense z-score of 1.35 and a pLI score of 0.90 while in CDKN1A, a protein of only 164 amino acids and not (yet) linked to any disease, more missense and loss-of-function variants were observed than expected resulting in a lower missense z-score and pLI score, respectively (z = 0.01, pLI = 0.03). The gene discussed is CDKN1A; the disease is Dystonia.