ADM and colitis: In addition to this, Kono et al. (2011) suggested that HAS, an active ingredient of Z. bungeanum pericarps, at doses of 0.3, 3.0, and 30 μmol/L, showed notable effects on improving the release of adrenomedullin (ADM) from intestinal epithelial cells in a dose-dependent manner [57]; in addition, they also showed that HAS (0.3 mg/kg) could markedly enhance the colonic blood flow in colitis rats.