HO-1 activator CoPP can reduce the expressions of TLR2, TLR4, IRAK-4 and TRAF6, and markedly increases the expressions of TLR negative regulators, such as SOCS-1, IRAK-M and SHIP-1, in ischemia/reperfusion liver injury in rat [17]. This evidence concerns the gene IRAK4 and ischemia.