NFE2L2 and endothelial dysfunction: Furthermore, Jeong et al. reported that piceatannol had a protective effect against palmitic acid (PA)-induced endothelial dysfunction by inducing NF-E2-related factor-2 (Nrf2)-dependent expression of hemeoxigenase-1 (HO-1), which inhibits PA-induced inflammation, oxidative stress and reduction of eNOS activity [35].