NLRP3 and Parkinson disease: Recently, we demonstrated in a DAergic neuronal cell culture model that mitochondria-impairing pesticides compromise mitochondrial dynamics (structure and function) by inhibiting mitochondrial complex-I.21 Here, we demonstrate that impairing mitochondrial function in primary microglial cells, which had been treated with the classical PD mitochondrial neurotoxicant rotenone and the acaricide tebufenpyrad, may play an important role in inducing the NLRP3 inflammasome.