CASP1 and Alzheimer disease: Recent studies have implicated inflammasome activation in inflammatory neurodegenerative disorders25,26 like Alzheimer’s disease (AD), multiple sclerosis, and traumatic brain injury (TBI).25,27 Inflammasomes are multiprotein oligomers mainly formed by ASC, caspase-1, and the inflammasome component (e.g., NLRP3, NLRP1, NLRC4, AIM2).