The downregulation of miR-1251-5p and miR-34a-5p might alleviate cognitive deficit by increasing the activity of disintegrin and metalloprotease 10 (ADAM10), a major α-secretase in brain that is capable of attenuating the production of Aβ by cleavage of APP, resulting in soluble APPα [27]. The gene discussed is APP; the disease is Cognitive impairment.