ANGPTL4 and atherosclerosis: The positive relationship of ANGPTL4 activity with increased plasma level of TG-rich VLDL lipoproteins is seen in human with less-of-function variance ANGPTL4 E40K as well as ANGPTL4-deficient or liver-specific overexpression transgenic mice [52–54]; however, transgenic overexpression of ANGPTL4 suppresses foam cell formation to reduce atherosclerosis development in atherosclerosis-prone E3L mice [55].