Since the phosphorylation status of PPARγ is directly linked to “pathological stimuli” such as a high-fat diet, obesity, and inflammation commonly seen in T2DM patients, the prominent activity of Chi in this regard in addition to its pan agonist activity can thus act cooperatively to rebalance glucose, FA uptake, and substrate utilization in energy production upon insulin resistance and obesity, which may improve the clinical prognosis of T2DM patients over time. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.