While silencing or depletion of SUN2 in cell lines has been shown to have either no impact or very modest impact on HIV-1 infection (167, 170), silencing in primary T cells inhibited infection and produced a large defect in replication assays, leading the authors to surmise that SUN2 acts as a cofactor for HIV-1 (168). This evidence concerns the gene SUN2 and HIV-1 infection.