The spleen is likely a significant contributor to elevated BDNF with exercise via the release of platelets (Matthews et al., 2009; Cho et al., 2012) and the magnitude of this release appears to be exercise intensity-dependent (exercise-induced thrombocytosis; Chamberlain et al., 1990; Hulmi et al., 2010). Here, BDNF is linked to Thrombocytosis.