Hu J. et al. (2016) reported that Lut up-regulated autophagy through Mst1 inhibition which alleviated post-infarction cardiac dysfunction in the Lut pretreatment group, enhanced autophagic flux, and lessened the aggresomes accumulation in neonatal cardiomyocytes in hypoxia model. Furthermore, in Mst1+/- murine model, the protective effects of Lut were abolished (Hu J. et al., 2016). This evidence concerns the gene MST1 and infarction.