CD8A and neoplasm: Consistent with a predominant role for H-2Kb molecules in the T cell-based cytotoxic response to D122 tumor (Eisenbach et al., 1984; Mandelboim et al., 1992; Plaksin et al., 1992), the capacity of 7A7 and AG1478-treated D122 to stimulate D122-reactive CD8+ T cells was strongly blocked by the addition of an anti-H-2Kb antibody, whereas the presence in the culture of an anti-H-2Db antibody did not reduce the tumor recognition (Figure 5B).