GWAS suggests that several genes (ABCA7, CD33, CLU, CR1, EPHA1, HLA-DRB5/DRB1, INPP5D, MEF2C, and MS4A) regulating clearance of misfolded proteins mediated by glia and the inflammatory reaction could increase the risk of AD in LOAD. Here, ABCA7 is linked to Alzheimer disease.