OPA1 and Alzheimer disease: However, our results are in agreement with findings presented in AD mice models and cortical AD samples that showed mitochondrial fragmentation (Wang et al., 2008; Cai and Tammineni, 2016), accompanied with an increase in DRP1 (Manczak et al., 2011) and a decrease in total OPA1 levels (Manczak et al., 2011).