In addition to these inflammatory molecules, several adipokines such as lipocalin-2/neutrophil gelatinase-associated lipocalin (ngal), adiponectin, resistin are secreted and are known to be responsible, although at different extents and directions, for the low level of systemic inflammation present in metabolic syndrome associated with obesity. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.