To further elucidate the circuit mechanism underlying PRRT2-related dyskinesia in the cerebellum, we generated a mouse line (GluN2C-iCre;Prrt2−/−) with ablation of PRRT2 in cerebellar GCs (Figure 5D-5F), but not in other cerebellar cells, by crossing Prrt2loxP/loxP mice with GluN2C-iCre mice35. This evidence concerns the gene GRIN2C and drug-induced dyskinesia.