Smedley et al. [41] evaluated 49 amelanotic melanomas and created a cost-effective and efficient immunodiagnostic cocktail panel containing antibodies against PNL2, Melan-A, TRP-1, and TRP-2 that had 100% specificity and 93.9% sensitivity in identifying canine oral amelanotic melanocytic neoplasms. This evidence concerns the gene MLANA and melanoma.