CDKN2B and cancer: Therefore, the comparative analysis of cytogenetic and molecular mapping of the genetic defects at human chromosome 9p21 and the corresponding canine chromosome 11 identified frequently deleted regions encoded by the INK4A/ARF/INK4B locus with a highly conserved order of genes (Figure 4) that are concurrently lost in many cancers recapitulating the strong similarities in genetic alternations and cancer predisposition between humans and dogs.