In fact, altogether, deletions or point mutations causing shifting of reading frame and altered expression located mostly in exon 1α have been found in cancers from humans, dogs and mice suggesting that specific mutation mapping in p16/INK4A and its regulation are not limited to these cancer types (for example, melanomas and breast cancers) but also occur in other tumors commonly encountered in mammalian species with neoplasms or uncontrolled cellular growth [21,71,72,77,78]. This evidence concerns the gene CDKN2A and cancer.