The human classification of breast cancers based on expression profile of luminal epithelial specific genes and hormone receptors including estrogen receptor 1 (ESR1), progesterone receptor (PR) and proto-oncogenes such as epidermal growth factor receptors (EGFR/HER2), have also identified similar molecular subtypes in CMTs, but unlike human subtypes, these are not routinely investigated for CMTs during clinical diagnosis [15,16]. The gene discussed is ESR1; the disease is breast carcinoma.