There have been mutations in several genes identified as associated with human ARVC, in particular, mutations in the five desmosomal genes—desmoplakin, plakophilin 2, desmoglein 2, desmocollin 2, and junction plakoglobin (DSP, PKP2, DSG2, DSC2, and JUP) [84]. The gene discussed is DSP; the disease is arrhythmogenic right ventricular cardiomyopathy.