There have been mutations in several genes identified as associated with human ARVC, in particular, mutations in the five desmosomal genes—desmoplakin, plakophilin 2, desmoglein 2, desmocollin 2, and junction plakoglobin (DSP, PKP2, DSG2, DSC2, and JUP) [84]. This evidence concerns the gene PKP2 and arrhythmogenic right ventricular cardiomyopathy.