CYCS and endometrial cancer: It is known that the favourable advantages and toxic effects of PtAcacDMS on endometrial cancer cells (HeLa) are due to a rapid and sustained apoptotic response characterized by (i) mitochondrial depolarization, (ii) cytosol accumulation of cytochrome c, (iii) translocation from cytosol to mitochondria of some proapototic proteins (the well-known Bax and the truncated form of Bid), (iv) activation of caspase 7 and 9, and v.