A simple analysis of cancer genomic data using cBioPortal (Cerami et al., 2012) suggests INPP4B is not frequently mutated in human cancer and there is no striking correlation between mutation in PTEN and INPP4B. However, significant co-reductions in INPP4B and PTEN expression have been noted in human breast, ovarian, and thyroid cancers (Fedele et al., 2010, Gewinner et al., 2009, Kofuji et al., 2015, Vo and Fruman, 2015). The gene discussed is PTEN; the disease is cancer.