Further, INPP4B has been recently identified as a conditional tumor suppressor, and a plausible mechanism of action has been constructed based on its ability to act as a specific PI(3,4)P2 4-phosphatase, thus limiting the activation of AKT (Fedele et al., 2010, Gewinner et al., 2009). The gene discussed is INPP4B; the disease is neoplasm.