Other neuropsychiatric manifestations include psychosis, with hallucinations a common feature of patients with Morvan’s syndrome who most commonly have coexistence of both LGI1 and CASPR2 antibodies.13 Also, personality change and depression are frequently observed.20 As these are also sometimes features of patients with dominant epilepsy presentations, one challenge for the field is to better define the concept of ‘isolated autoimmune epilepsy’. This evidence concerns the gene LGI1 and Morvan syndrome.