Both are susceptible to temporal lobe epilepsy and, perhaps even more intriguing is the shared vulnerability to reflex seizures triggered by loud noises, including telephone ringing.15 46 This overlap might relate to the neuroanatomical distribution of LGI1 in the temporal lobe or represent common molecular mechanisms secondary to loss of LGI1 function. The gene discussed is LGI1; the disease is temporal lobe epilepsy.