Together with high level expression of HDAC1 and HDAC2 in human BCC samples (Supporting Information, Fig. 8), our findings therefore warrant further studies of 4SC‐202 and other class I HDACi as combination or second‐line drugs to tackle the problem of frequent SMOi‐resistance development observed in HH‐driven cancers such as BCC. This evidence concerns the gene HDAC1 and skin basal cell carcinoma.