In melanoma cells, TRPM1 is prevalent in highly dynamic intracellular vesicular structures [165, 298].TRPM3 (reviewed by [301]) exists as multiple splice variants four of which (mTRPM3α1, mTRPM3α2, hTRPM3a and hTRPM31325) have been characterised and found to differ significantly in their biophysical properties. The gene discussed is TRPM1; the disease is melanoma.