Additionally, the administration of numerous agents such as atorvastatin, minocycline, edaravone, cannabinol, niaspan, and Tricin 7-glucoside was also shown to inhibit HMGB1 expression in brain ischemic tissue during the acute phase after stroke in experimental models of MCAO, so alleviating cerebral injury [1,125,131–135]. Here, HMGB1 is linked to stroke disorder.