The key results of the present work include the following: (i) novel insight into aberrant lipid metabolism in IDH‐mutant gliomas, (ii) demonstration of low energy potential in IDH‐mutant gliomas, (iii) identification of potential compensatory pathways to maintain redox balance and establishing a novel prognostic factor in patients with oligodendroglial glioma subtype. Here, IDH1 is linked to glioma.