Recently, Nezu et al. [27] identified miR-135b as a key regulator in myxoid liposarcoma, the overexpression of which would favor neoplastic invasion and metastasis through the direct suppression of thrombospondin 2 (THBS2), a protein that mediates cell-extracellular matrix interactions. Here, THBS2 is linked to myxoid liposarcoma.