Liu et al. [11] have demonstrated that high glucose treatment induced much higher levels of apoptosis and caspase-3 activity in rat RPTCs overexpressing AGT in comparison to control RPTCs in vitro, and induction of diabetes in transgenic mice that overexpressing AGT in RPTCs led to significant increases in apoptosis of RPTCs compared with diabetic nontransgenic littermates, moreover, the above effects were markedly attenuated by insulin and/or RAS blockers. The gene discussed is AGT; the disease is diabetes mellitus.