SELP and acute respiratory distress syndrome: The literature describes several roles for platelets in the pathogenesis of ARDS, in both animal and human studies; platelet depletion has been shown to correlate with reduced recruitment of neutrophils in lung interstitium [63] and increased platelet-derived thromboxane-A2 and P-selectin correlated with increased neutrophil activation, in a mouse model of ARDS [28].