CD34 and Miyoshi myopathy: Accordingly, the presence of CTCs was documented not only in symptomatic MM, but also in SMM and MGUS.65, 66 Paiva et al.67 demonstrated that in MM the number of CTCs fluctuates throughout the day, following a circadian rhythm similar to CD34+ cells, suggesting that CTCs may egress to PB to colonize other sites during the patients’ resting period.