Given that Hsp’s are expressed across a host of cancers (García-Morales et al., 2007; Nylandsted et al., 2002; Sauvageot et al., 2009), it will be important to determine whether Daam2 engages the Hsp chaperone system to facilitate VHL degradation in glioma and other malignancies. The gene discussed is VHL; the disease is central nervous system cancer.