PDGFB and central nervous system cancer: Misuraca et al. [25] have established low- and high-grade glioma, which phenocopies diffuse intrinsic pontine glioma, resulting from injection of Pax3-Tv-a;Trp53fl/fl mice with RCAS-PDGFB and RCAS-Cre, with or without RCAS-H3.3K27M.