PTEN and glioblastoma: Molecular characteristics typical of IDH-wild type glioblastoma include TERT promorter mutations (present in ~ 80% of cases), homozygous deletion of CDKN2A/CDKN2B (~ 60%), loss of chromosomes 10p (~ 50%) and 10q (~ 70%), EGFR alterations (i.e. mutation, rearrangement, altered splicing, and/or amplification; ~ 50%), PTEN mutations(25–30%), and PI3K mutations (~ 25%) [4, 5].