In order to optimize the patient’s clinical outcomes, the synchronous nodal metastases were submitted for IHC, only to find the nodal lesions shared the same negative HER-2 status with the primary tumor, which indicated that HER-2 protein expression of nodal lesions was also suppressed by NAC, as Oldham et al. [13] demonstrated that paclitaxel downregulated HER2 expression in MDA-MB 453 cells. Here, ERBB2 is linked to neoplasm.